01
Autosomal recessive
Two healthy carriers can unknowingly pass the same serious condition to their child.
25%typical risk per pregnancy when both parents carry the same recessive condition
The future of reproductive medicine
Prevent 1 in 3 diseases
in your future children.
Identify serious inherited risks before pregnancy. Understand every option. Keep lifelong control of your genomic data.
Parent 01
Parent 02
Risk identified
Know before you pass it on.
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Paris · Madrid · Everywhere
01 — The shift
Medicine waits for inherited diseases to appear before treating them.
We believe families should have the option to act before transmission.
Jouvence is building the reproductive-risk layer of precision medicine — combining parental sequencing, clinical interpretation, genetic counselling and access to reproductive options.
Information creates options. The decision always belongs to the family.
The opportunity
1 in 3 diseases could eventually be addressed before transmission.
02
Autosomal dominant
A single pathogenic variant can be enough to transmit a serious inherited condition.
50%typical risk per pregnancy when one parent carries a dominant variant
03
X-linked conditions
Risk can differ by the carrier parent, the child’s sex and the condition’s expression.
1 genecan change the story of an entire family
Jouvence begins with serious, clinically interpretable and medically actionable monogenic conditions.
Explore 10 well-known inherited conditions 10 of 6,000+ ↗ Explore Jouvence Graph Interactive disease map ↗Beyond panel-scale screening
Thousands of known risks.
One whole-genome foundation.
Conventional carrier panels publicly advertise hundreds of genes. Jouvence’s current research catalogue uses whole-genome data to interrogate thousands of evidence-backed gene–disease links.
2.6%
A question worth answering before pregnancy
Could you be among the couples whose screening reveals a high-impact reproductive risk?
One broad preconception-screening cohort identified 2.6% of couples as having an increased reproductive genetic risk. Results vary by population and test scope. A finding does not make IVF mandatory: genetic counselling comes first, and IVF with PGT-M is one option among several.
Catalogue snapshot · July 2026. Counts are distinct ClinVar/GenCC evidence units, not a claim that every condition is currently eligible for PGT-M. Published commercial panels include up to about 790 genes; reported high-impact couple yields include 1.0% and 2.6% in different cohorts.
The Jouvence journey
One sequence.
A lifetime of insight.
Your genome should not disappear into a laboratory report. It should become a portable, understandable resource for your family and your future health.
01
Sequence
Both future parents are sequenced once, creating a complete and reusable genomic foundation.
02
Understand
Relevant pathogenic variants are interpreted in the context of the couple and their family project.
03
Choose
Families receive genetic counselling and a clear explanation of every reproductive option.
04
Reuse
Your information remains accessible for future pregnancies, prevention and personalised care.
Beyond reproduction
Your genome is more than a reproductive test.
The same information can help you understand your own health, identify certain inherited predispositions and prepare more personalised prevention with healthcare professionals.
Your
genome
Reproductive risk
Understand what you may pass on.
Actionable findings
Prepare relevant prevention.
Pharmacogenomics
Inform future medication choices.
Research
Contribute only when you choose.
Sequence once. Learn for life.
Participant-owned by design
You have never had this much control over your genetic data.
Access everything easily. Understand who can use it. Approve every new purpose. Change your mind at any time.
Explicit consent
Nothing happens without a clear yes from you.
Easy withdrawal
Stop any new use of your data whenever you choose.
Radical transparency
See who requested access, why and for how long.
True portability
Download and take your genomic information with you.
Information, not instruction
Your family.
Your values.
Your choice.
IVF, without the mythology
Not what the clichés suggest.
IVF studies often compare older people with pre-existing fertility difficulties against younger, fertile couples. That can exaggerate the part attributable to treatment — but careful sibling studies still find small residual differences for some outcomes. The honest comparison keeps both facts.
“IVF is always slower.”
About 92% of young couples conceive within 12 natural cycles. Once suitable euploid embryos exist, IVF can reach 95.2% cumulative sustained implantation after just 3 transfers. In that situation, IVF is clearly faster.
“IVF is risky.”
The risks are real, but often overstated. Age, infertility and underlying health explain part — not all — of the observed difference. Modern protocols and single-embryo transfer reduce avoidable risks, especially multiple pregnancy.
“PGT guarantees a healthy baby.”
PGT-M tests a known familial variant. It does not edit an embryo, cover every future condition or guarantee implantation, pregnancy or birth.
Side by sideNatural conceptionIVF + PGT-M
Opportunities
Usually one ovulated egg per cycle
Several oocytes and embryos may be developed in parallel
Visibility
Fertilisation and early development remain unseen
Fertilisation, development and the familial variant can be assessed before transfer
Time
12 natural cycles for about 92% clinical pregnancy at ages 19–26
3 euploid transfers for 95.2% sustained implantation
Sources and denominators: NICE natural-conception guidance, Pirtea et al., euploid transfers, ASRM safety context, and HFEA treatment risks. Transfer rates are conditional on having suitable embryos; they are not rates per couple starting IVF.
The team
Built at the intersection of genomics, AI and human health.
01Founder
Jérémie Kalfon
Computational biologist · researcher · engineer · entrepreneur
PhD in AI from Institut Pasteur and ENS, formerly at the Broad Institute of MIT and Harvard, and former team lead at Whitelab Genomics. Jérémie has built open-source genomics and AI systems designed to turn complex biological data into useful, accountable tools.
Start something generational
There is a place for you in the future we are building.
01For families
Understand your inherited risks before pregnancy.
Reserve two whole-genome sequencing kits — one for each prospective parent. No payment today.
Pre-order your test ↗02For builders
Build at the edge of genomics and reproductive medicine.
We want exceptional scientists, clinicians, engineers and operators.
Build with us ↗03For investors
Back the reproductive-risk layer of precision medicine.
Join us in building a new category of preventive health.
Read the whitepaper ↗This is Jouvence