A glimpse of what is possible
From cystic fibrosis and sickle cell disease to Huntington’s, thousands of serious inherited conditions can be traced to a known genetic change. Once a family’s variant is identified, reproductive options can help prevent it from being passed on.
When the change responsible for a condition is known in a family, embryos created through IVF can be tested for that specific change before transfer. This is PGT-M: selection, not gene editing.
A lifelong condition in which thick, sticky mucus damages the lungs, digestive system and other organs.
An inherited blood disorder that can cause severe pain, anaemia, infections and progressive organ damage.
A progressive brain disorder affecting movement, thinking and mental health, usually beginning in adulthood.
A severe childhood-onset disorder that progressively weakens skeletal and heart muscle, mainly in boys.
A neuromuscular condition that causes progressive weakness and can affect breathing and movement from infancy.
Inherited bleeding disorders in which blood does not clot normally, causing prolonged or spontaneous bleeding.
A common inherited cause of intellectual disability and developmental differences, often more severe in boys.
A blood disorder that reduces haemoglobin production and can cause severe anaemia requiring lifelong transfusions.
A rare disorder in which toxic material accumulates in nerve cells; its classic form causes rapid neurological decline.
A metabolic disorder in which phenylalanine can build up and damage the brain unless carefully managed.
And this is only the beginning
Jouvence’s ambition reaches across serious monogenic conditions with known causes and clinically meaningful reproductive options — not just the conditions people already recognise.
View the HFEA condition directory ↗PGT-M requires IVF and a condition-specific test. It can identify embryos that do not carry a known familial variant before transfer. It does not edit genes, guarantee pregnancy or guarantee the birth of an unaffected child. Feasibility depends on the familial variant, embryo availability, laboratory validation and the family’s circumstances.
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